螺旋级联向的纳米组件通过铁灭消除了内瘤细菌,以增强STING驱动的抗瘤免疫力
Xinxin Li1, Zexi Han1, Shihao Sun1
1State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China.
ACS applied materials & interfaces
|January 23, 2026
概括
这项研究引入了一种新的性纳米组件,该组件针对瘤细胞和细胞内细菌. 它触发了细菌铁亡,并激活了天生的免疫力,导致了强大的抗瘤反应,并重新编程了瘤微环境.
科学领域:
- 生物医学工程 生物医学工程
- 癌症研究 癌症研究
- 免疫治疗是一种免疫疗法.
背景情况:
- 内细菌会影响瘤的进展和免疫抑制.
- 准细胞内细菌并将它们的存在转化为抗瘤免疫信号是具有挑战性的.
研究的目的:
- 开发一种性超分子纳米组件,用于向瘤细胞和细胞内细菌.
- 为了利用细菌铁灭菌来产生强大的抗瘤免疫力.
主要方法:
- 设计了一种合纳米组件 (ZnO2@CDP/Fc-DA),利用d-alanine进行准.
- 该系统在瘤溶解体中释放H2O2和Fc-DA,诱导细菌铁亡并激活cGAS-STING通路.
- 在瘤细胞中通过ROS介导的铁亡促进免疫细胞死亡 (ICD).
主要成果:
- 纳米组件诱导了细菌铁亡并释放了微生物DNA,激活了cGAS-STING通路.
- 协同激活STING和瘤细胞ICD重新编程了免疫抑制瘤微环境.
- 观察到主要和转移性瘤的显著抑制,与l-enantiomer对照相比,效率更高.
结论:
- 奇拉性引导的纳米组件有效地准细胞内细菌和瘤细胞.
- 细菌性铁死作为抗瘤免疫力的强有力的触发剂.
- 这一策略为微生物组增强的癌症免疫疗法提供了一种有前途的方法.
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