贝瓦西祖马布相关的脏不良事件表明卵巢癌的预后更好:双边血管内皮生长因子抑制的双边血管内皮生长因子
Cristina Riaza1, Marta Álvarez-Nadal1, Antonio Casado2
1Nephrology Department, San Carlos Clinical University Hospital, IdISSC, Madrid, Spain.
像高血压这样的脏事件发生在34.7%的卵巢癌患者中,这些患者接受了bevacizumab治疗. 这些事件,特别是高血压,与更长的存活率有关,这表明有效的癌症治疗.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- 贝瓦西祖马布是一种VEGF-A抑制剂,是卵巢癌的标准.
- 脏不良事件 (高血压,蛋白尿,AKI) 是已知的副作用.
- 这些事件发生率,危险因素和死亡率影响的数据有限.
研究的目的:
- 为了确定接受贝瓦西祖马布的卵巢癌患者脏事件的发生率.
- 为了确定与这些事件相关的危险因素.
- 评估事件与患者死亡率之间的关联.
主要方法:
- 在147名接受贝瓦齐祖马布治疗的卵巢癌患者 (2011-2023) 进行了回顾性单一中心研究.
- 根据CTCAE v5.0和KDIGO指南定义的脏事件 (高血压,蛋白尿,AKI等级≥2).
主要成果:
- 34.7%的患者在平均52个月的随访期间经历了事件.
- 高血压是最常见的事件 (27.9%).
- 高血压史是唯一独立的危险因素 (p=0.0078).
- 患有事件的患者的存活时间显著增加 (p=0.0243).
- 在多变量分析中,脏事件是预防死亡的保护因素.
结论:
- 脏事件影响超过三分之一的贝瓦西祖马布治疗的卵巢癌患者.
- 虽然高血压是一个危险因素,但脏事件可能表明有效的VEGF抑制和改善的结果.
- 积极监测和管理事件对于优化治疗和患者生存至关重要.
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