在黑人和白人子宫内膜癌幸存者中,便和阴道微生物组概况模式:北卡罗来纳州的一项试点研究
Mu Jin1, Temitope Keku2, Amber McCoy2
1Department of Epidemiology, University of North Carolina (UNC) Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.
PloS one
|January 23, 2026
概括
化疗和放射治疗等子宫内膜癌治疗可能会改变阴道微生物群,减少有益细菌. 癌症幸存者可以自行收集便和阴道样本.
科学领域:
- 妇科瘤学 妇科瘤学
- 微生物组研究 微生物组研究
- 癌症的生存率 癌症的生存率
背景情况:
- 子宫内膜癌是美国最常见的妇科癌症.
- 癌症治疗可以改变微生物群,影响幸存者的健康.
- 阴道微生物群的多样性与健康结果有关,而乳酸菌的优势是有利的.
研究的目的:
- 评估子宫内膜癌幸存者的便和阴道微生物群落的变化.
- 评估在这个人群中进行微生物组分析的自我采样的可行性和可接受性.
主要方法:
- 50名子宫内膜癌幸存者通过邮件收到阴道和便样本的自我收集套件.
- 调查问卷收集了有关人口统计,职能和自我抽样观点的数据.
- 医疗记录提供了瘤和治疗信息.
- 细菌16S rRNA amplicon测序的特征是微生物群的特征.
主要成果:
- 阴道微生物群的多样性因癌症治疗而异 (单独使用化疗/辐射与手术).
- 在化疗或放射后观察到更高的阴道微生物多样性.
- 与单独手术相比,在接受化疗或放射治疗的幸存者中,乳酸菌的占主导地位较低.
结论:
- 对癌症幸存者来说,自我收集微生物组样本是可行的,也是可以接受的.
- 化疗和放射治疗可能会对子宫内膜癌幸存者的阴道微生物组产生负面影响,减少乳酸菌并增加多样性.
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