淋巴细胞计数与PD-L1免疫相关不良事件之间的相关性
Zachary Sawyer1,2,3, Mark Sorial4, Justin C Liauw1,2
1Rhode Island Hospital, Department of Pharmacy, Providence, RI, USA.
概括
在接受PD-L1抑制剂的患者中,较高的基线淋巴细胞计数 (≥2000细胞/毫米3) 并没有增加与免疫相关的不良事件 (irAEs) 的风险. 这一发现与以前对PD-1抑制剂的研究形成鲜明对比,表明不同的irAE配置文件.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床研究 临床研究
背景情况:
- 免疫检查点抑制剂,包括PD-L1抑制剂,对于治疗固体瘤至关重要.
- 与免疫相关的不良事件 (irAEs) 是这些疗法的常见副作用.
- 以前的研究将更高的绝对淋巴细胞计数 (ALC) 与使用PD-1抑制剂增加的irAE风险联系起来.
研究的目的:
- 调查基线绝对淋巴细胞计数 (ALC) 与治疗PD-L1抑制剂的患者中irrAEs发生率之间的相关性.
- 为了确定ALC≥2000细胞/毫米3是否在PD-L1抑制剂治疗的背景下预测irAEs.
主要方法:
- 追溯性队列研究,利用来自学术卫生系统的电子健康记录.
- 包括患有固体瘤的成年患者,接受他们的第一个PD-L1抑制剂剂量 (2022年1月至2023年12月).
- 排除了先前有irrAEs,血液恶性瘤,其他免疫疗法或最近使用皮质类固醇的患者;在治疗后30天内需要基线ALC.
主要成果:
- 分析了210名患者,186人患有ALC<2000细胞/mm3,24人患有ALC≥2000细胞/mm3.
- 发生了20个2级+irAE事件:19个在ALC<2000组和1个在ALC≥2000组.
- 在基线ALC≥2000细胞/mm3和2级+irAE发病率 (OR0.503;P=0.515) 之间没有发现统计学意义上的相关性.
结论:
- 基线绝对淋巴细胞计数≥2000细胞/毫米3似乎不能预测在接受PD-L1免疫检查点抑制剂治疗的患者中发生irrAEs的发生.
- 这一发现表明,在PD-1和PD-L1抑制剂治疗之间,ALC对irAEs的预测值可能会有所不同.
- 需要进一步的研究,以了解与PD-L1抑制剂相关的irAEs的特定生物标志物和风险因素.
相关概念视频
Correlation and Causation
42.4K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.4K
What is the Immune System?
127.2K
Overview
127.2K
Correlations
35.8K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.8K
PD Controller: Design
636
In automotive engineering, car suspension systems often employ Proportional Derivative (PD) controllers to enhance performance. PD controllers are utilized to adjust the damping force in response to road conditions. A controller, acting as an amplifier with a constant gain, demonstrates proportional control, with output directly mirroring input.
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
636
Correlation
14.8K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
14.8K
Local Anesthetics: Adverse Effects
780
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
780


