长期COVID和肌痛性脑膜炎/慢性疲劳综合征的共享自主表型
Peter Novak1,2, David M Systrom2,3, Alexandra Witte1
1Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
PloS one
|January 23, 2026
概括
长期COVID和ME/CFS具有类似的自主和神经系统问题,包括血流减少和小纤维神经病变. 这些发现表明这些致残的后感染性疾病的共同潜在原因.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
背景情况:
- 长期的COVID和肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 正在使多系统性疾病失效,具有重叠的症状,如脑雾,疲劳和静止不耐症.
- 共同的特征表明了共同的病理生理机制,但由于症状量化方面的挑战,这些仍然不太了解.
研究的目的:
- 调查长期COVID和ME/CFS之间的共享病理生理机制.
- 为了比较自主功能,脑血管血流和长期COVID,ME/CFS和高移动埃勒斯-丹洛斯综合征 (hEDS) 患者的神经病变发现.
主要方法:
- 追溯分析自主测试,头脑图,脑间多普勒测试大脑血流速度 (CBFv),皮肤活检小纤维神经病变 (SFN) 和侵入性心肺运动测试 (ICPET).
- 评估了143名长期COVID患者,170名ME/CFS患者,73名健康对照和290名hEDS患者.
主要成果:
- 长期的COVID和ME/CFS显示,正静性CBFv,广泛的自主性衰竭,SFN,姿势性心跳动综合征 (POTS),神经性正静性低血压和预负载衰竭的减少相似.
- 患有hEDS的患者表现出更严重的外周神经退行.
- 实验室测试没有区分长期COVID和ME/CFS.
结论:
- 长期的COVID和ME/CFS表现出大脑血管血流,自主反射和SFN的共同失调,表明了共同的潜在病理生理学.
- 在hEDS的独特发现表明潜在的重叠或不同的综合征.
- 需要进一步的研究来阐明确切的关系和机制.
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