相关实验视频
Updated: Jan 25, 2026

05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
2.2K
多金属共同暴露与甲状腺癌风险之间的关联在中国山西:一项病例对照研究
Yifan Xie1, Yuanzheng Ding2, Yuli Gao2
1Academy of Medical Sciences, Shanxi Medical University, Taiyuan, China.
PloS one
|January 23, 2026
概括
这项研究表明,同时暴露于和等环境金属会增加甲状腺癌的风险,而自由甲状腺素 (FT4) 会调解这种影响. 金属混合物监测和FT4查对于预防至关重要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 环境金属是已知的甲状腺致癌物.
- 同时暴露于多种金属和甲状腺癌的机制尚不清楚.
研究的目的:
- 调查环境金属共同暴露对甲状腺癌风险的集体影响.
- 为了确定特定的金属及其相互作用导致甲状腺癌.
- 探索自由甲状腺素 (FT4) 在金属诱导的甲状腺癌发生过程中的调解作用.
主要方法:
- 在368名甲状腺癌患者和使用ICP-MS的对照组中,量化了18种金属的血度.
- 应用WQS回归,BKMR建模,相互作用分析和因果调解分析.
- 从医疗记录中使用的自由甲状腺素 (FT4) 水平.
主要成果:
- 在一些病例中观察到血中Cr,Co,Mn,Ni,Cu,As,Cd和Sn的水平升高.
- Sn,Cd,Ni和As被确定为有风险的金属;Sb,Pb和Zn显示了相反的关联.
- 发现了Cd和Sn之间的协同作用;FT4介导了Sn,Cd,Ni和As的甲状腺癌风险的46-69.3%.
结论:
- 同时暴露于特定的环境金属显著增加了甲状腺癌的风险.
- 自由甲状腺素 (FT4) 在金属诱导的甲状腺癌中起着关键的调解作用.
- 建议将金属混合物监测和FT4查纳入预防策略.
相关概念视频
Genome-wide Association Studies-GWAS
15.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.4K
Alkali Metals
24.3K
Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals
Table 1: Properties of the alkali metals
24.3K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
417
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
417
Bonding in Metals
52.2K
Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.
52.2K
Metallic Solids
20.5K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.5K
The Thyroid Gland
6.8K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.8K

