生物废弃物衍生光碳点基生物降解机械强的水凝,用于刺激响应性非类固醇抗炎药物 (NSAID) 输送
Sina M Matalqah1, Venkata Ramana Singamaneni2, Patibandla Jahnavi3
1Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.
PloS one
|January 23, 2026
概括
这项研究开发了先进的水凝,使用从甘中提取的生物废物衍生碳点 (BCD) 来进行控制的非类固醇抗炎药物 (NSAID) 输送. 这些生物相容的水凝提供可调节的,环境可持续的药物释放,特别是在酸性条件下.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 开发可持续和有效的药物输送系统对于向治疗至关重要.
- 从农业废物中获得的生物材料为先进应用提供了一种绿色替代方案.
- 响应刺激的水凝可以提供受控的药物释放配置文件.
研究的目的:
- 从甘包中合成生物废物衍生的碳点 (BCDs).
- 将BCD纳入可生物降解的水凝中,以提高机械性能和对刺激有反应的药物输送.
- 评估BCD装载的水凝用于非类固醇抗炎药物 (NSAID) 输送的体外性能和生物相容性.
主要方法:
- 从甘包中合成BCD的热水合成.
- 使用FTIR,拉曼光谱和光发光的BCD的表征.
- 制造装有BCD的水凝和评估机械性能.
- 在不同pH条件下进行的ibuprofen体外释放研究.
- 细胞毒性测试用于评估生物相容性.
主要成果:
- 在BCD中,表现出有利的表面功能组和光.
- 含有BCD的水凝显示出增强的机械强度和pH响应的药物释放.
- 在酸性pH (3.8) 时,布洛芬的释放速度更快,与病理环境一致.
- 药物释放遵循希古奇模型,表明扩散控制.
- BCDs和BCD装载的水凝显示出高生物相容性和持续的细胞活力.
结论:
- 生物废弃物衍生的碳点可以有效地集成到水凝中,以提供对刺激敏感的NSAID.
- 开发的系统在机械上是坚固的,生物相容的和环境可持续的.
- 这种从农业废物中采用的绿色方法对先进的生物医学平台和可控的药物输送具有前途.
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