相关实验视频

Updated: Jan 25, 2026

A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg
04:34

A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg

Published on: May 31, 2019

9.7K

基于罗皮瓦卡因的区域麻醉在急性隔间综合征的猪模型中,尽管隔间压力升高,但具有肌肉保护作用

Gerhard Fritsch1,2,3, Philipp Thaler2, James Ferguson2

  • 1AUVA Trauma Center Salzburg, Department of Anesthesiology and Intensive Care Medicine, Academic Teaching Hospital of the Paracelsus Medical University, Salzburg, Austria.

Anesthesiology
|January 23, 2026
PubMed
概括

使用罗皮瓦卡因 (RPVC) 的区域麻醉在急性隔间综合征 (ACS) 中改善了组织完整性,尽管隔间压力更高. 这项研究表明RPVC在ACS中具有保护作用,这需要进一步的临床研究.

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Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
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Compartment Models: Single-Compartment Model01:14

Compartment Models: Single-Compartment Model

The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this...
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Three-Compartment Open Model01:06

Three-Compartment Open Model

The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
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Two-Compartment Open Model: Overview01:05

Two-Compartment Open Model: Overview

Multicompartmental models are crucial tools in pharmacokinetics, providing a framework to understand how drugs move within the body. The two-compartment model is a crucial subtype, segmenting the body into central and peripheral compartments. The central compartment represents areas with high blood flow, such as plasma and highly perfused organs like the kidneys and liver, while the peripheral compartment signifies tissues with lower blood flow, like adipose tissue and muscle tissue.
The...
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One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
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Two-Compartment Open Model: Extravascular Administration01:12

Two-Compartment Open Model: Extravascular Administration

The two-compartment model for extravascular administration represents a drug's absorption and distribution process. It features a central compartment, where the drug is first absorbed, and a peripheral compartment, which illustrates the drug's distribution throughout the body. The rate of change in drug concentration in the central compartment is calculated by three exponents: absorption, distribution, and elimination.
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