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Updated: Jan 25, 2026

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在生物物理动力学上训练的蛋白质语言模型告知突变效应.

Chao Hou1, Haiqing Zhao2,3, Yufeng Shen1,4,5

  • 1Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032.

Proceedings of the National Academy of Sciences of the United States of America
|January 23, 2026
PubMed
概括

SeqDance和ESMDance是新的蛋白质语言模型,使用生物物理数据捕获蛋白质动态. 这些模型改善了蛋白质行为和突变效应的预测,优于现有的方法.

关键词:
分子动力学分子动力学突变的影响 突变效应正常模式分析正常模式分析蛋白质语言模型

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