巨大的内斯林-2的取决于力量的结构动态
Fei Shang1,2,3, Yuhang Zhang1,2,3, Jiaqing Ye1,2,3
1Department of Physics, College of Physical Science and Technology, State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361005, China.
概括
尼斯-2巨型作为一个分子吸收器,维持细胞结构的力量. 它的光谱重复域在pN力下展开和重新折叠,调节细胞力学和蛋白质相互作用.
科学领域:
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
- 结构生物学 结构生物学
背景情况:
- 涅斯连接细胞骨与细胞核,经历生理力.
- 尼斯在强力作用下的机械动力学尚不清楚.
研究的目的:
- 为了研究光谱重复 (SR) 域在巨型内斯-2.2中的力动力学.
- 探索纳斯二在核骨-细胞骨机械传导中的作用.
主要方法:
- 基于磁的单分子操纵.
- 分子动力学模拟.分子动力学模拟.
- 阿尔法结构预测.
主要成果:
- 在PN尺度上,Nesprin-2的SR域表现出明显的展开和重新折叠动态.
- 尼斯二作为一个分子吸收剂,在很大的位移上在几 pN 之内稳定力.
- pN级的力量通过域动态调节内斯-蛋白相互作用.
结论:
- 巨型内斯林-2具有重要的机械特性,对于细胞力传输至关重要.
- 了解内斯二的机械性质,可以了解机械转导通路.
相关概念视频
Intermolecular Forces in Solutions
38.9K
The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
38.9K
Electromotive Force
29.8K
Electricity is generated by either electrons or ions flowing through a solution or a conducting medium. This flow of electrons or specifically electrical charge is defined as an electric current. When electrons move through a wire, they generate an electric current. It can be recalled that in a redox reaction, electrons are lost and gained. In the spontaneous redox reaction of zinc with copper, when zinc is immersed in a copper ion solution, a transfer of electrons from one substance to...
29.8K
Contact-dependent Signaling
46.9K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
Gap Junctions
In animal cells, gap junctions are formed...
46.9K
Intermolecular Forces
70.6K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
70.6K
Temperature Dependence on Reaction Rate
88.7K
The Collision Theory
Atoms, molecules, or ions must collide before they can react with each other. Atoms must be close together to form chemical bonds. This premise is the basis for a theory that explains many observations regarding chemical kinetics, including factors affecting reaction rates.
The collision theory is based on the postulates that (i) the reaction rate is proportional to the rate of reactant collisions, (ii) the reacting species collide in an orientation allowing contact between...
Atoms, molecules, or ions must collide before they can react with each other. Atoms must be close together to form chemical bonds. This premise is the basis for a theory that explains many observations regarding chemical kinetics, including factors affecting reaction rates.
The collision theory is based on the postulates that (i) the reaction rate is proportional to the rate of reactant collisions, (ii) the reacting species collide in an orientation allowing contact between...
88.7K
Additional Subnuclear Structures
5.3K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals.
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
5.3K


