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前列腺癌的焦点冷疗法. 格里森是否会影响结果?
Kinga Mate1,2, Pedro de Pablos-Rodríguez3, Marta Burbano Herraiz4
1Department of Urology, CHU de Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe.
概括
焦点冷疗法在局部性前列腺癌 (PCa) 中显示出有希望的短期结果. 基线格里森得分在本次微创治疗研究中没有显著影响无复发生存率.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 最少侵入性的手术
背景情况:
- 局部性前列腺癌 (PCa) 管理选择包括激进的治疗方法和微创的焦点疗法.
- 焦点冷疗法是局部PCa的新兴选择,但与基线疾病严重程度相比,其结果需要进一步调查.
研究的目的:
- 评估局部性前列腺癌 (PCa) 焦点冷治疗的瘤结果.
- 评估基线格莱森等级组 (GG) 对焦点冷治疗后无复发生存的影响.
主要方法:
- 对111名局部PCa患者的回顾性分析,这些患者接受了焦点冷治疗 (2014-2024年).
- 排除标准包括先前的治疗或<12个月的随访;所有患者都接受了MRI和跨关节活检.
- 分析了无复发和无激素治疗的生存期,比较了基线GG1和GG>1组之间的结果.
主要成果:
- 随访时间中位数为35个月;78%的患者接受了确认性活检.
- 现场复发发生在10%的患者中,现场外复发发生在23%的患者中.
- 在基线GG组之间没有观察到复发率或三年无复发存活率 (63%) 或无激素治疗存活率 (85%) 的显著差异.
结论:
- 焦点冷疗法在局部前列腺癌中显示出有利的短期瘤结果.
- 基线格里森得分似乎没有显著影响焦点冷治疗后无复发生存率.
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