双边乳房植入物相关的爱斯坦-巴尔病毒阳性扩散型大B细胞淋巴瘤:一个病例报告和文献综述
Hsiao-Han Huang1, Chien-Liang Ho
1From the Division of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Annals of plastic surgery
|January 23, 2026
概括
这项研究报告了一例罕见的双边乳房植入物相关的爱斯坦-巴尔病毒阳性扩散大B细胞淋巴瘤 (BIA-EBV阳性DLBCL). 这些发现强调了潜在的诊断挑战,以及在疑似病例中需要仔细评估两个乳房的必要性.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 免疫学 免疫学 免疫学
背景情况:
- 与乳房植入物相关的形大细胞淋巴瘤 (BIA-ALCL) 不常见,特别是在有纹理的植入物中.
- 与乳房植入物相关的爱斯坦-巴尔病毒阳性扩散性大B细胞淋巴瘤 (BIA-EBV阳性DLBCL) 是罕见的,通常是单边的.
研究的目的:
- 为了呈现双边BIA-EBV阳性DLBCL的独特案例.
- 讨论BIA-EBV阳性DLBCL的诊断挑战,病理发现和潜在的预防措施.
- 审查关于BIA-EBV阳性DLBCL的现有文献.
主要方法:
- 一个79岁的妇女的案例报告与双边乳房植入物.
- 双边全囊切除术用于单边囊收缩.
- 免疫组织化学染色和EBER在现场杂交用于诊断.
主要成果:
- 在手术后对双边BIA-EBV阳性DLBCL的最终诊断.
- 瘤细胞对LCA,CD20,CD79a,CD30,BCL2,MUM1和PD-L1.1呈阳性反应
- 观察到高Ki67指数 (60%-70%),在手术后43个月没有疾病复发.
结论:
- 潜在的EBV感染与这些软性淋巴瘤的发病有关.
- 由于异常呈现,可能会出现延迟诊断.
- 在特定情况下,可以考虑预防性双边全囊切除术.
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