通过基于高频超声波的卷积神经网络识别和定位乳腺瘤组件,结合组织病理学注册:前性研究
Jia-Qian Yao1, Wen-Wen Zhou1,2, Zhi-Fei Chai3
1Department of Medical Ultrasonics, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, China, +86-020-8776 518.
这项研究开发了一种卷积神经网络,用于在超声波图像中识别乳腺癌区域,通过用整个幻灯片图像 (WSI) 记录它们来实现高精度. FCN-101模型在精确确定癌症区域以改善乳腺癌诊断方面表现出卓越.
科学领域:
- 使用先进的人工智能 (AI) 和深度学习技术进行医学图像分析.
- 专注于计算病理学和瘤学中的数字成像.
- 将放射学 (超声波) 与病理学 (组织病理学) 整合起来,以加强诊断.
背景情况:
- 乳腺癌生物学非常多样化,需要改进的非侵入性诊断工具.
- 目前的方法很难以无创的方式准确捕捉微观组织病理学模式.
- 迫切需要先进的成像技术来补充现有的诊断程序.
研究的目的:
- 使用卷积神经网络 (CNN) 在乳房超声图像中识别癌症区域.
- 为了实现精确的空间记录灰度超声图像和整个幻灯片图像 (WSIs) 的活检标本.
- 在超声波数据中开发和评估CNN模型,用于对乳腺癌的像素级分类.
主要方法:
- 预计将招募105名乳腺成像报告和数据系统4或5类乳腺病变的参与者.
- 收集超声波图像,活检组织样本和相应的WSIs.
- 开发CNN模型 (FCN-101,DeepLabV3) 用于识别癌细胞,使用注册的超声波和WSI数据.
- 使用像素精度,子相似系数和回忆的定量评估;临床应用的定性评估.
主要成果:
- 与DeepLabV3.3.3相比,FCN-101模型显示出更高的像素精度 (86.91%) 和Dice相似度系数 (77.47%).
- 这两种模型在预测癌症区域方面表现良好,FCN-101在癌症区域预测方面表现出色.
- 视觉化证实了超声波图像和WSIs中确定的癌症区域之间的高一致性.
结论:
- 成功建立了一种用于乳房WSI和超声波图像的空间注册的新技术.
- 先进的CNN在超声波图像中的像素水平上准确地识别和定位乳腺癌区域.
- 组织病理学WSI作为可靠的参考标准,用于验证人工智能驱动的超声波图像分析.
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