相关实验视频
Updated: Jan 25, 2026

05:39
Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
Published on: December 27, 2024
874
脊髓洞性血管瘤切除的预后因素和症状患者的最佳手术时间
Seyeon Kim1, Yun Choi1, Hangeul Park2
11College of Medicine, Seoul National University, Seoul.
Journal of neurosurgery. Spine
|January 23, 2026
概括
脊髓洞性血管瘤 (CH) 的切除提供了良好的结果. 对于功能依赖患者来说,在8.2个月内进行手术可以改善结果,初始独立性和宫位置预测成功.
科学领域:
- 神经外科 神经外科
- 血管神经学 血管神经学
- 脊髓病理学 脊髓病理学
背景情况:
- 脊髓洞性血管瘤 (CH) 是一种罕见的骨髓内血管病变.
- 这些病变带有出血和渐进的神经衰退的风险.
- 手术切除是症状性CH的标准治疗方法,但最佳时间是有争议的.
研究的目的:
- 为了评估脊髓CH的手术结果.
- 为了确定术后功能独立的预后因素.
- 为了确定功能依赖患者的最佳外科手术时间.
主要方法:
- 对40名接受CH切除的患者 (2002-2023) 的回顾性分析.
- 修改的麦考米克 (MMC) 尺度用于评估功能独立 (1-2分) 和依赖 (3-5分).
- 对临床结果和与功能独立相关的因素的分析;依赖性患者的症状持续时间决定了最佳时间.
主要成果:
- 62.5%的患者在平均随访48.4个月后实现了功能独立.
- 最初的功能独立性 (OR 8.41) 和宫CH位置 (OR 5.42) 是独立性的重要预测因素.
- 对于依赖患者,早期手术 (在8.2个月内) 与改善的MMC得分相关 (p=0.002).
结论:
- 脊髓CH患者的术后功能独立性是由初始功能状态和宫病变位置预测的.
- 对于最初依赖的患者来说,最优的手术时间是在症状出现后的8.2个月内.
- 需要对更大的队列进行进一步的研究,以改进外科手术时间和患者选择标准.
相关概念视频
Spinal Cord
1.6K
The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
1.6K
The Spinal Cord
31.6K
The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
31.6K
Spinal Cord: Information Processing
3.3K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
3.3K
Spinal Cord: Gross Anatomy
5.5K
The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
5.5K
Factors Affecting Protein-Drug Binding: Patient-Related Factors
312
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
312
Spinal Cord: Cross-sectional Anatomy
4.5K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
4.5K

