安西氨酸-氨酸共颜色增强脂质体封装:机制,双层相互作用和持续释放性能
Bowen Luo1, Xiang Li2, Xiuyu Jiang2
1Collaborative Innovation Center of Fragrance Flavour and Cosmetics, Shanghai 201418, China; Faculty of Flavour Fragrance and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.
Food chemistry
|January 23, 2026
概括
配色增强了脂质体输送的安东素 (ACN) 通过增加它们的疏水性. 这种新的策略提高了封装效率和ACN和其他爱水化合物的持续释放.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 药品制造 药品制造 药品制造
背景情况:
- 传统的脂质体制备方法难以有效地封装水友性化合物.
- 安西氨酸 (ACN),有价值的生物活性化合物,由于其水友性质,通常表现出不良的稳定性和传递性.
研究的目的:
- 研究共颜色化作为一种非共价策略,以增强脂质体中抗素 (ACN) 的输送.
- 为了提高ACN的封装效率和持续释放性质,使用Quercetin (QTI) 进行疏水性修饰.
主要方法:
- 素 (ACN) 与素 (QTI) 的共颜色,形成疏水复合物.
- 使用聚醇稀释方法制备脂质体以封装ACNs@QTI复合体.
- 使用FTIR,DSC和光光谱学对脂质体的表征.
- 在体外释放研究以评估持续释放性能.
主要成果:
- 配色通过π-π堆叠和疏水相互作用形成稳定的ACN@QTI复合体,增强了ACN的疏水性.
- 脂质体封装了ACNs@QTI复合体,封装效率明显更高 (81.5 ± 0.6%) 和粒子大小为166.4 ± 7.9 nm.
- 光谱分析证实了ACNs@QTI复合体和脂质体膜之间更强的相互作用.
- 实验室释放研究表明,修饰后的脂质体具有优越的持续释放能力.
结论:
- 配色是一种实用和有效的非共价策略,用于改善脂体封装水友生物活性物,如安氨酸.
- 这种方法提高了ACN的稳定性和交付性,在食品和制药行业有潜在的应用.
- 这些发现为利用共色素来改善通过脂质体传递各种水溶性化合物的基础.
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