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性激素和结核病:对免疫调节,易感性和疾病发病的影响
Eshet Gebrie1, Habtamu Wondifraw Baynes1, Birhan Mulugeta2
1Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia.
雌激素,孕和等性激素显著影响结核病 (TB) 的易感性和进展. 了解这些性别差异对于开发有效的宿主导疗法来对抗Mycobacterium tuberculosis (MTB) 至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 结核病 (TB) 呈现出显著的性别差异,成年男性更容易受到影响.
- 性类固醇激素 (雌激素,孕,) 调节免疫反应,对控制Mycobacterium结核病 (MTB) 至关重要.
研究的目的:
- 审查和综合当前关于性激素如何影响结核病免疫反应的研究.
- 突出结核病研究中需要性别和荷尔蒙意识的研究设计.
主要方法:
- 人类和动物研究的叙事审查.
- 用PubMed,ScienceDirect和谷歌学者进行的文献搜索.
主要成果:
- 性激素不同调节促炎性 (例如IFN-γ,TNF-α) 和抗炎性 (例如IL-4,IL-10) 细胞因子.
- 雌激素的作用因度而异;孕激素和通常会抑制Th1免疫力.
- 人类数据显示,男性在怀孕期间更容易受到感染,女性在怀孕期间风险增加,与荷尔蒙效应一致,但临床荷尔蒙数据不一致.
结论:
- 性激素介导的免疫调节是结核病易感性和发病的关键因素.
- 未来的结核病研究必须纳入性别和激素剂量意识的设计,以优化宿主导疗法.
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