多发性硬化症中的思维理论:双盲tDCS和视频培训后的三个月后续效果,试点研究
Lidia Ammendola1, Daniela Malangone2, Maria Cropano3
1UOSD Second Neurology, Multiple Sclerosis Center, University of Campania 'Luigi Vanvitelli', Napoli, Italy.
Multiple sclerosis and related disorders
|January 23, 2026
概括
心理理论 (ToM) 训练改善了多发性硬化症 (PwMS) 患者的认知和口头情感ToM. 将训练与前额外横直流刺激 (tDCS) 结合起来,可以增强这些益处.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 康复医学 康复医学 康复医学
背景情况:
- 心理理论 (ToM) 缺陷在患有多发性硬化症 (PwMS) 的个体中很普遍.
- 生态有效的ToM培训和跨直流刺激 (tDCS) 是潜在的干预措施.
- 了解ToM培训和tDCS对PwMS认知和情感ToM的综合影响至关重要.
研究的目的:
- 评估为PwMS提供一个生态有效的ToM培训计划的可行性.
- 调查前额叶皮层tDCS是否增强了对TOM训练对认知和情感TOM的影响.
- 通过口头和非口头方式检查ToM的改进.
主要方法:
- 研究1:单个案例设计,3名PwMS接受了为期16周的基于视频的ToM培训,在基线,干预后和后续评估.
- 研究2:随机对照试验,12名PwMS接受了16周的ToM训练,并与活性 (dlPFC或vmPFC) 或假装tDCS (2mA,20分钟,每周两次) 相结合.
主要成果:
- 研究1的参与者在认知性ToM (口头和非口头) 和口头情感ToM方面有所改善.
- 与假装组相比,研究2的活跃tDCS组在认知和情感ToM方面表现出更大的改善.
结论:
- 在PwMS中,ToM培训对认知和口头情感ToM有益,特别是当被前额tDCS增强时.
- 非言语情感TOM表现出对干预的抵抗力,表明需要专门的策略.
- 研究结果支持个性化,多模式的方法,用于多发性硬化症的社会认知康复.
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