低体重指数对中风结果的影响:倾向匹配分析
1Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
概括
体重不足患者 (BMI <19.9) 在缺血性中风后面临更糟糕的结果,包括功能恢复不佳和肺炎风险增加. 营养状况对于中风护理计划和风险分层至关重要.
科学领域:
- 神经学 神经学
- 临床营养学 临床营养学
- 公共卫生 公共卫生
背景情况:
- 身体质量指数 (BMI) 显著影响中风的结果.
- 体重不足 (BMI < 19.9) 对中风后预后的具体影响尚不清楚.
- 这项研究调查了体重不足状态和缺血性中风后的不良结果之间的联系.
研究的目的:
- 为了评估缺血性中风患者的功能和临床结果,体重不足的BMI与理想的BMI (20-24.9) 相比.
- 为了确定低BMI是否是一个危险因素,导致中风后复苏较差和并发症增加.
主要方法:
- 利用了来自西奈山卫生系统的TrinetX数据,用于成人缺血性中风患者.
- 队列根据BMI分类:理想体重 (20-24.9) 和体重不足 (<19.9).
- 倾向性得分匹配平衡每组1600名患者进行2年结果评估,包括修改的兰金度量表 (mRS),肺炎和存活率.
主要成果:
- 体重不足的患者表现出较高的功能性结局 (mRS>2:18.1%vs14.4%) 和较低的2年生存概率 (79.3%vs83.7%).
- 肺炎在体重不足组中发生的频率更高 (8.8%对6.9%).
- 在重复性中风,运动缺陷,出血转变或需要先进的干预措施 (如血栓抑制剂或血栓切除术) 中没有发现显著差异.
结论:
- 体重不足状况与功能性结果较差,肺炎风险增加以及缺血性中风后生存率降低有显著关联.
- 在计划中风后护理时,应考虑营养状况.
- 识别体重不足的患者可以有助于中风风险分层和管理.
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