结节性多炎与孤立的器官参与,需要切除生殖泌尿系统
Busra Yaprak Bayrak1, Selva Kabul2, Suheda Zeynep Seday1
1Department of Pathology, School of Medicine, Kocaeli University, Kocaeli, Turkey.
Annals of diagnostic pathology
|January 23, 2026
概括
单独的器官参与多关节炎 (PAN) 是罕见的,但可能导致不可逆转的损伤. 这项研究强调了在没有全身症状的情况下,在无法解释的脏或丸血管事件中考虑PAN的重要性.
科学领域:
- 血管医学 血管医学
- 类风湿病学 类风湿病学
- 病理学 病理学 病理学
背景情况:
- 多关节炎 (PAN) 通常是一种多系统的死性血管炎,影响中等大小的动脉.
- 罕见地,PAN可能会出现孤立的器官参与,可能会在诊断前导致器官损失.
- 目前关于分离器官PAN的数据有限,主要来自病例报告.
研究的目的:
- 以回顾性评估临床表现,诊断发现和患者与孤立器官PAN.结果.
- 强调罕见的PAN呈现的诊断挑战和临床意义.
- 突出组织病理学在诊断PAN中的作用,特别是在异常呈现的情况下.
主要方法:
- 在多个中心对8名被诊断患有PAN的患者进行了回顾性分析.
- 对临床数据,成像学,血清学和组织病理学的审查.
- 专注于患有主要是孤立器官干扰的患者.
主要成果:
- 在8名患者中,有5名患者患有孤立器官PAN,主要影响脏或丸.
- 尿生殖系统事件,包括出血和心脏病发作,是常见的症状.
- 组织病理学证实了中型动脉的死亡性动脉炎;血清学通常是无诊断的 (ANCA负).
- 在灾难性的血管并发症导致器官切除后,经常确立诊断.
结论:
- 隔离器官PAN是一种罕见但重要的实体,由于异常呈现,可以在晚期诊断.
- 临床病理相关性和外科病理对于诊断至关重要.
- 在无法解释的脏或丸血管灾难中,即使没有全身症状,也应该考虑PAN.
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