肠道微生物群塑造了人类和小鼠的呼吸
Ariel J Hernandez-Leyva1, Amalia Z Berna2, Maggie H Bui1
1Division of Allergy and Immunology, Department of Medicine, and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cell metabolism
|January 23, 2026
概括
呼吸中的挥发性有机化合物 (VOC) 反映了肠道微生物组的组成和功能. 这项研究确定了微生物衍生的VOCs在呼吸中,为肠道健康的非侵入性诊断铺平了道路.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在人类健康中起着至关重要的作用.
- 目前用于肠道微生物组分析的诊断方法通常具有侵入性和耗时性.
- 需要非侵入性诊断方法来促进基于微生物群的治疗方法的实施.
研究的目的:
- 调查呼吸中挥发性有机化合物 (VOC) 是否可以作为肠道微生物组合和功能的非侵入性生物标志物.
- 在人类和 gnotobiotic 小鼠中,建立呼吸 VOC 概况和肠道微生物群状态之间的相关性.
- 展示呼吸分析在预测与疾病相关的特定肠道细菌的丰富性方面的潜力.
主要方法:
- 气色谱-质谱法 (GC-MS) 用于分析呼吸中的VOCs.
- 从健康的儿童和与人类肠道微生物群结合的 gnotobiotic 小鼠收集了呼吸样本.
- 评估了肠道微生物组的组成和功能,并与呼吸挥发性细胞数据相关联.
主要成果:
- 呼吸中的VOC成分与健康儿童的肠道微生物组组成和功能有显著的相关性.
- 鼠的呼吸 VOC 档案显然受到肠道微生物群的影响.
- 特定的微生物挥发性有机化合物在 gnotobiotic 小鼠体内 in vivo 被确定.
- 呼气分析成功预测了患有喘的儿童中Eubacterium siraeum的丰富性.
结论:
- 微生物衍生的VOC存在于哺乳动物的呼吸中,直接反映了肠道细菌的新陈代谢.
- 呼吸分析是一种有前途的非侵入性方法,用于诊断与肠道微生物群相关的疾病.
- 这项研究为开发用于肠道健康的基于呼吸的新型诊断奠定了基础.
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