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Updated: Jan 25, 2026

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics
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Published on: June 23, 2022

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脑溶酶体的细胞类型分辨蛋白质图谱确定SLC45A1相关疾病为溶酶体疾病

Ali Ghoochani1, Julia C Heiby2, Eshaan S Rawat1

  • 1Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; The Institute for Chemistry, Engineering and Medicine for Human Health (Sarafan ChEM-H), Stanford University, Stanford, CA 94305, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.

Cell
|January 23, 2026
PubMed
概括

研究人员绘制了脑细胞溶解体图,揭示了细胞特异性蛋白质,并确定SLC45A1是神经元特异性的糖载体. 失去SLC45A1会导致溶解体功能障碍和神经退行,将其重新定义为溶解体储存障碍 (LSD).

关键词:
其他:星球细胞大脑溶解体储存疾病溶酶体微质细胞神经退行症神经元体细胞蛋白质组学

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