黄:识别,抗真菌敏感性和,因菌素诱导的矛盾生长
Gülşah Ece Özmerdiven1, Arzu İrvem1
1Microbiology Department, Kanuni Sultan Suleyman Research and Training Hospital.
Indian journal of medical microbiology
|January 23, 2026
概括
CHROMagarTM Candida Plus有效地识别了Candida auris,而VITEK®2和SensititreTM YeastOneTM在抗真菌敏感性测试中显示出差异,错误率很高,并观察到caspofungin的效应.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 黄是一种新兴的多药耐药性真菌病原体,导致侵入性感染.
- 准确的鉴定和抗真菌敏感性测试 (AST) 对于有效治疗C. auris感染至关重要.
- 目前的诊断方法需要评估,以获得最佳的临床效用.
研究的目的:
- 评估VITEK®2和CHROMagarTMCandida Plus对C. auris的鉴定对MALDI-TOF MS.的疗效.
- 为了比较VITEK®2和SensititreTM YeastOneTM (SYO) 之间的抗真菌敏感性测试结果.
- 评估错误率并识别潜在问题,如AST中的老效应.
主要方法:
- 分析了63个C. auris分离物.
- VITEK®2和CHROMagarTM的Candida Plus鉴定与MALDI-TOF MS.进行了比较.
- 使用VITEK®2和SYO进行了抗真菌敏感性测试,并计算了绝对一致,重大错误 (ME) 和非常重大错误 (VME) 率.
- 研究了MIC50,MIC90值,抵抗率和效应.
主要成果:
- 对于C. auris的形态,CHROMagarTM Candida Plus显示了100%的一致性,而VITEK®2与MALDI-TOF MS.达成了74%的一致性.
- 与VITEK®2.2相比,在SYO中观察到AMPHOTERICIN B,FLUCONAZOLE和VORICONAZOLE的MIC值更高,而在VITEK®2中则观察到更高的MIC值.
- 没有检测到对米卡金或anidulafungin的耐药性; caspofungin的耐药性与效应和SYO的高稀释范围有关.
- 维特克®2通常产生的MIC50/MIC90值低于SYO,除了安福特B.
结论:
- 在资源有限的环境中,CHROMagarTM Candida Plus 作为一种可行的查工具,用于识别C. auris.
- 在VITEK®2和SYO之间的抗真菌敏感性测试中发现了显著的不相容性和高的ME/VME率.
- 在SYO方法中证实了效应对菌素,突出了解释结果的潜在挑战.
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