跨种族,种族和地理位置的炎症性肠道疾病的表型差异:对237项基于人口的研究进行系统审查
Ameer Halim1, Agnes H Y Ho2, Wasuwit Wanchaitanawong3
1Division of Gastroenterology, Boston Medical Center, Boston, Massachusetts; Boston University School of Medicine, Boston, Massachusetts.
概括
地理和种族因素显著影响炎症性肠病 (IBD) 现型,在亚洲人群中观察到克罗恩病 (CD) 和家族病史的变异. 移民也影响IBD流行病学和表现.
科学领域:
- 胃肠病学和流行病学
- 炎症性肠病 (IBD) 研究研究
- 人口健康研究 人口健康研究
背景情况:
- 地理位置和种族越来越多地被认为是影响全球炎症性肠病 (IBD) 增加的因素.
- 了解这些人口影响对于理解IBD流行病学和全球表现型表达至关重要.
- 之前的研究表明,IBD在不同种族和地理区域的表现可能存在差异.
研究的目的:
- 进行系统性审查和元分析,以更新对跨民族和移民对IBD流行病学和表型的影响的理解.
- 为了比较全球不同种族群体的人口统计,表型和结果的综合估计.
- 根据地区和移民身份,专门分析亚洲人群中的表型变异.
主要方法:
- 包括所有基于人口的队列研究,报告克罗恩病 (CD) 或性结肠炎 (UC) 现型和/或结果,直到2024年12月.
- 对人口统计数据,疾病表型和患者结果的系统审查和元分析.
- 对跨种族群体的综合估计进行比较分析,并根据地区和移民状况对亚洲人口进行集中比较.
主要成果:
- 对237项涉及1,251,682名IBD患者的研究进行了分析.
- 亚洲人 (24%) 与白人 (14%) 和西班牙裔 (13%) 个人 (p <0.01) 相比,在克罗恩病 (CD) 中出现周疾病的比率更高.
- 对于性结肠炎 (UC) 周围部疾病发病率没有发现显著差异.
- 在亚裔个人中,IBD家族病史在中东 (12%) 比南亚 (3%) 个人 (p < 0.01) 更常见,在移民 (12%) 与本地居民 (4%) (p < 0.01) 之间更为普遍.
- 性别分布不同,男性在白人和亚洲人群中占主导地位,女性在黑人人群中占主导地位 (p < 0.01).
结论:
- 在全球各族群之间存在IBD表型和结果的持久差异.
- 这些发现强调了在IBD管理和研究中考虑种族和地理位置的重要性.
- 未来的研究应该纳入多种不同种群的多原子数据,以探索观察到的IBD变异的生物学基础.
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