体重调整的腰指数 (WWI) 和多病症之间的关联:来自NHANES的证据和查尔斯研究的前性验证
Xiao-Rong Ye1, Ding-Qi Shi1, Rui-Xuan Li1
1School of Health Management, Guangzhou Medical University, Guangzhou, 511436, China.
Experimental gerontology
|January 23, 2026
概括
体重调整后腰部指数 (WWI) 是多病症的更好的预测指标,而不是BMI或WC. 较高的第一次世界大战水平表明风险增加,这表明它在慢性疾病的早期预防策略中有用.
科学领域:
- 代谢健康和慢性疾病流行病学
- 用于健康风险评估的生物标志物
背景情况:
- 肥胖显著增加了慢性疾病的负担,但传统的指标,如BMI和WC不充分评估中心脂肪.
- 体重调整腰部指数 (WWI) 提供了一种新的方法来测量腹部脂肪分布,可能克服BMI和WC的限制.
- 关于第一次世界大战与多病症相关的证据有限,需要进一步调查.
研究的目的:
- 使用NHANES数据调查第一次世界大战和多病症之间的关联.
- 在一个潜在的中国队列 (CHARLS) 中验证这些发现.
- 为了比较第一次世界大战的预测性能与BMI和WC的多病症.
主要方法:
- 分析NHANES 2017-2023年数据 (n>20年) 的加权抽样.
- 定义多病症是≥2个并存的慢性疾病.
- 多变量逻辑回归,受限立方 (RCS),通用添加模型 (GAM) 和ROC曲线分析在NHANES;使用Cox回归和RCS在CHARLS的外部验证.
主要成果:
- 第一次世界大战显示,与NHANES的多发病率有显著的积极关联 (OR=1.74,P<0.001).
- 最高的第一次世界大战四分位数与多发病率增加三倍以上相关 (OR=3.04,P<0.001).
- 与BMI和WC相比,WWI显示出更高的区分能力 (AUC=0.709);查尔斯验证支持了这些发现.
结论:
- 第一次世界大战是多病症的一个一致而重要的预测指标,其表现优于BMI和WC.
- 虽然主要是线性,但在极端的第一次世界大战水平的潜在非线性关联需要进一步研究.
- WWI 作为一种实用的工具,用于识别高风险个体,并为早期预防策略提供信息.
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