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杏仁体-海马体电路通过mGluR5-依赖的BDNF信号传递来调节应对压力

Tae-Eun Kim¹, Tae-Yong Choi², Ja Wook Koo¹

¹Emotion, Cognition & Behavior research group, Korea Brain Research Institute (KBRI), Don-gu, Daegu, 41062, Republic of Korea; Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Dalseong-gun, Daegu, 42988, Republic of Korea.

Molecules and cells

|January 23, 2026

概括

研究人员发现,激活底侧杏仁体 (BLA) 到腹部海马体 (vHPC) 电路可显著改善应对压力. 这一途径通过影响mGluR5-BDNF信号传递来调节压力恢复,提供一种潜在的基因治疗标.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
精神病学是一个精神病学.

背景情况:

与压力相关的精神疾病涉及前额皮质和海马体功能障碍.
这些障碍背后的特定电路机制尚不清楚.
识别关键的神经回路对于理解应对压力行为至关重要.

研究的目的:

识别调节应对压力行为的特定神经回路.
阐明压力恢复背后的分子机制.
探索针对与压力相关疾病的特定分子通路的治疗潜力.

主要方法:

研究了基底侧杏仁体 (BLA) 到腹腔海马体 (vHPC) 和BLA到中间前额叶皮层 (mPFC) 电路.
在动物中利用慢性社会失败压力模型.
分析了mGluR5表达和CREB介导的BDNF转录的变化.
执行特定电路的行为分析,以评估应对行为.

主要成果:

BLA-vHPC电路被确定为应对压力行为的关键调节器.
慢性压力在vHPC和mPFC中减少了mGluR5的表达.
激活BLA-vHPC电路比激活BLA-mPFC电路显著改善了应对行为.
降低的vHPC mGluR5损害了CREB介导的BDNF转录,将其与被动应对联系起来.

结论:

BLA-vHPC电路在压力恢复中发挥着关键作用.
降低vHPC中的mGluR5会损害BDNF转录,导致被动应对策略.
mGluR5-BDNF通路代表了与压力相关的疾病和基因治疗干预的有希望的治疗标.

关键词:

底侧桃体 (BLA) 是一个甲本托普性谷氨酸受体5 (mGluR5) 的使用应对压力的行为.腹腔海马体 (vHPC) 是一个大脑衍生神经营养因子 (BDNF)

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