登革热流行病和疫苗开发的现状
Shiqi He1, Dongying Fan1, Yuqing Guo1
1Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Virologica Sinica
|January 23, 2026
概括
全球登革热病例正在激增,在2024年报告的病例超过1400万. 本综述详细介绍了登革热的趋势和疫苗的进展,这对于对抗这种蚊子传播疾病的公共卫生战略至关重要.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 登革热是一种蚊子传播的病毒性疾病,在全球范围内越来越普遍,特别是在热带和亚热带地区.
- 近年来登革热发病率急剧增加,2023年和2024年登革热爆发创纪录,影响全球数百万人.
- 气候变化,城市化和旅行增加等因素有助于登革热病毒 (DENV) 的传播扩大.
研究的目的:
- 系统地审查登革热最近的全球和区域流行病学趋势.
- 总结目前在登革热疫苗研发方面的进展和挑战.
- 为公众健康预防和控制战略提供信息的资源.
主要方法:
- 对登革热最近的流行病学数据进行系统审查.
- 全球和区域登革热发病率和爆发模式的分析.
- 关于目前正在开发和临床使用的登革热疫苗候选药物的概述.
主要成果:
- 全球登革热病例急剧增加,到2024年将超过1400万例,在美洲,亚洲和非洲报告有重大爆发.
- 中国在2024年经历了十年来最大的登革热疫情,广东省是主要的热点.
- 有两种登革热疫苗 (Dengvaxia,Qdenga) 获得许可,包括TV003/TV005在内的几种候选疫苗在临床试验中显示出前景.
结论:
- 由于环境和社会变化,登革热的传播正在迅速扩大,需要紧急的公共卫生干预.
- 疫苗开发是优先事项,目前正在进行的研究重点是实现对所有四种DENV血清型的均衡免疫力,并减轻抗体依赖增强 (ADE) 等风险.
- 本次审查强调了继续研究和战略实施疫苗和控制措施的关键需求,以应对日益增长的登革热全球负担.
更多相关视频
15:03Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes
Published on: July 4, 2007
11.3K
08:36Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
Published on: November 1, 2018
32.6K
相关概念视频
Vaccinations
51.3K
Overview
51.3K
Types of Fever
1.1K
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Here are the different types of fever:
1.1K
Patterns of Fever
3.8K
Before understanding the types and patterns of fever, it is essential to know its phases.
3.8K
Methods of reducing fever
1.3K
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
1.3K
Cancer Vaccines
989
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
989
Marcia's Theory of Identity Status
1.5K
James Marcia's identity status model provides a framework for understanding how adolescents navigate identity formation through varying degrees of exploration and commitment. Marcia's model builds on Erik Erikson's theories of psychosocial development, focusing specifically on how adolescents reconcile individual aspirations with societal expectations. His model describes identity formation as a dynamic process where adolescents move between different states depending on their level...
1.5K
