牛皮生物新用户中的感染风险:对法国国家健康数据系统的队列研究
Tran Trong Khoi Le1, Tat-Thang Vo1, Emilie Sbidian2
1EpiDermE Epidemiology in Dermatology and Evaluation of Therapeutics, EA7379, Paris Est Créteil University UPEC, F-94010, Créteil, France.
Journal of the American Academy of Dermatology
|January 23, 2026
概括
治疗牛皮的生物药物通常具有较低的感染风险. 在一项大型队列研究中,乌斯特基努马布和IL-23抑制剂在住院和门诊感染的总体风险最低.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药物监督 药物监督 药物监督
背景情况:
- 牛皮的治疗越来越多地涉及生物药物.
- 关于与牛皮治疗生物药物相关的感染风险的综合数据有限.
研究的目的:
- 评估用于牛皮的不同生物药物的住院和门诊感染风险.
- 在现实环境中比较各种生物病原体的感染风险概况.
主要方法:
- 一项队列研究利用了法国国家卫生数据系统 (2013-2022) 数据.
- 分析了39669名患有牛皮的成年新生物使用者.
- 结果包括感染住院的时间,首次门诊抗感染药物的使用时间和抗感染药物的覆盖范围.
主要成果:
- 住院感染发生率为每1000人/年27.1;中位数的抗感染覆盖率为5.5%.
- 与阿达利穆马布相比,乌斯特基努马布,塞库金努马布和里桑基祖马布在住院患者中感染风险较低.
- 乌斯特基努马布和IL-23抑制剂对首次住院或门诊感染事件的总体风险最低.
结论:
- 牛皮的生物药物与整体感染风险低相关.
- 乌斯特基努马布和IL-23抑制剂似乎在感染方面具有最有利的安全概况.
- 局限性包括缺乏临床数据和专注于全身抗感染药物.
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