在外周血液单核细胞中Hsa_circ_0053004的高表达与糖尿病视网膜病变中的内皮功能障碍相关
Xixi Zhang1, Jiahui Jiang1, Ying Chen2
1Wenzhou Medical University Eye Hospital, Wenzhou, China; The Affiliated Peoples Hospital of Ningbo University, Ningbo, China.
Experimental eye research
|January 23, 2026
概括
一种新的圆形RNA,hsa_circ_0053004,在糖尿病视网膜病变 (DR) 中显著升高. 这种生物标志物显示出诊断潜力,并与内皮功能障碍有关,这是DR进展的关键因素.
科学领域:
- 眼科医生 眼科 眼科
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因和糖尿病并发症.
- 循环RNAs (circRNAs) 正在成为潜在的生物标志物,但它们在DR病原发生中的作用尚不清楚.
研究的目的:
- 研究circRNAs在糖尿病视网膜病变中的作用和诊断潜力.
- 探索DR中差异表达的circRNAs的功能机制.
主要方法:
- 从DR患者的外周血液单核细胞 (PBMC) 和水性幽默的circRNA微阵列分析.
- 使用实时定量PCR验证候选circRNAs.
- 在人类视网膜微血管内皮细胞 (hRMECs) 中的功能测定和生物信息分析.
主要成果:
- hsa_circ_0053004在DR患者的PBMC和水性幽默中显著上调.
- 在hRMECs中,hsa_circ_0053004的过度表达促进了内皮功能障碍,部分通过miR-139-5p和miR-23a-5p.
- 接收器操作特征 (ROC) 分析证实hsa_circ_0053004对DR的强烈诊断能力.
结论:
- 在PBMC中检测到的hsa_circ_0053004是糖尿病视网膜病变的潜在诊断生物标志物.
- hsa_circ_0053004 通过影响内皮功能障碍,可能会导致DR的发病.
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