[胎儿状况产前诊断后继续怀孕:演变和影响]
Nicolas Bourgon1, Elsa Kermorvant-Duchemin2, Alexandre Lapillonne2
1Université Paris Cité, AP-HP, Hôpital Necker-Enfants malades, Service d'obstétrique maternité - médecine, chirurgie et imagerie fœtale, Paris F-75015, France.
Gynecologie, obstetrique, fertilite & senologie
|January 23, 2026
概括
严重胎儿诊断后的妊娠延续显著增加,但比诊断的速度慢. 新生儿存活率有所改善,持续怀孕不会导致新生儿死亡率的整体趋势.
科学领域:
- 围产儿医学 围产儿医学
- 公共卫生 公共卫生
- 医学伦理 医学伦理
背景情况:
- 根据法国法律,严重胎儿疾病的产前诊断允许终止妊娠.
- 持续怀孕的趋势及其围产期结果需要评估.
研究的目的:
- 评估严重胎儿疾病的产前诊断后持续怀孕的趋势.
- 评估与这些持续怀孕相关的围产期结局.
主要方法:
- 法国国家统计局和生物医学机构对公共数据 (2008-2022) 的时间序列分析.
- 每1000名活产儿分析的指标:严重的胎儿状况,终止授权,继续怀孕,新生儿死亡率和怀孕结果.
主要成果:
- 在产前发现的严重胎儿疾病从每1000个活产儿中从8.70增加到12.09 (2008-2022).
- 持续怀孕从0.60上升到2.69每1000个活产,这比诊断的增加要少 (p < 0.001).
- 在继续怀孕的新生儿中,28日新生儿存活率有所改善;新生儿死亡率比继续怀孕缓慢增加.
结论:
- 在重症胎儿状况的产前诊断后,怀孕结果的显著变化.
- 提出了临床,伦理和组织方面的挑战.
- 公共卫生政策需要加强围产期指标.
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