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在激光针治疗患有骨关节炎的老鼠期间,局部微循环水平的变化
Jae Yoon Park1, Cha Kyung Youn2,3, Sang-Mi Kang2
1Department of Electrical Engineering and Computer Science, DGIST, Daegu, Republic of Korea.
Journal of biophotonics
|January 23, 2026
概括
使用扩散斑点对比分析 (DSCA) 测量深层组织微循环,可以表明激光针在骨关节炎 (OA) 模型中的疗效. 血流指数的变化与治疗反应和炎症相关.
科学领域:
- 生物医学工程 生物医学工程
- 骨关节炎研究 骨关节炎研究
- 针研究 针研究
背景情况:
- 骨关节炎 (OA) 是一种退行性关节疾病,治疗选择有限.
- 评估治疗疗效,特别是对于像激光针这样的新疗法,需要可靠的生物标志物.
- 微循环在组织健康和炎症中起着至关重要的作用.
研究的目的:
- 评估深层组织微循环测量作为激光针治疗疗效的指标.
- 调查血流指数 (BFI) 变化与骨关节炎进展/治疗反应之间的相关性.
- 探索光谱分析和机器学习对分类治疗结果的有用性.
主要方法:
- 建立了一个骨关节炎 (OA) 鼠标模型,其中有四组:正常,OA和两组治疗组 (OA10,OA20),接受不同的激光剂量.
- 使用定制的扩散斑点对比分析 (DSCA) 系统在GB34和GB39针点附近测量深层组织微循环.
- 血液流量指数 (BFI) 记录在四个时间点 (T0-T3),并进行光谱分析.
主要成果:
- 甲状腺诱导导致BFI增加,在未经治疗的甲状腺大鼠中,BFI仍然升高.
- 激光针治疗组的BFI下降,表明微循环改善.
- 频谱分析发现了肌源性波段的显著变化,当BFI被纳入时,机器学习改善了组分类准确性.
结论:
- 通过DSCA进行深层组织微循环测量是评估OA激光针疗效的有希望的指标.
- BFI的变化反映了OA的急性炎症反应和解剖学指数.
- 这种方法提供了一个潜在的非侵入性工具,用于监测OA研究中的治疗有效性.
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