系统免疫疗法和向癌症治疗的眼科不良事件:一篇评论
Michael R Dong1, Zelia K Chiu1, Lyndell L Lim1,2,3,4
1Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.
Clinical & experimental ophthalmology
|January 23, 2026
概括
像免疫疗法这样的新型癌症疗法可以改善生存率,但也会导致严重的眼睛问题. 本综述详细介绍了这些与视力相关的副作用的原因,症状和治疗方法.
科学领域:
- 在瘤学瘤学.
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
背景情况:
- 系统性抗癌治疗,包括免疫疗法和向疗法,已经彻底改变了癌症护理,改善了患者的生存率.
- 这些新型疗法的使用不断扩大,导致眼科毒性越来越多地被认为是显著的不良影响.
- 眼科并发症可能会影响患者的生活质量和治疗坚持.
研究的目的:
- 提供与现代癌症疗法相关的眼部不良事件病理生理学的全面概述.
- 描述与各种类型的抗癌药物相关的眼科毒性临床谱.
- 概述当前管理策略来管理这些与视觉相关的副作用.
主要方法:
- 本综述综合了当前关于全身抗癌治疗对眼部毒性的文献.
- 它涵盖免疫检查点抑制剂和向疗法,包括MEK,BRAF,FGFR,ERK,EGFR,HER2,BTK,FLT-3,Bcr-Abl,ALK抑制剂和抗体药物合物.
- 讨论了病理生理学,临床表现和管理.
主要成果:
- 眼科不良事件是与先进的癌症治疗日益关注的问题.
- 可以发生各种各样的眼部毒性,根据药物类别而异.
- 了解机制是有效管理的关键.
结论:
- 眼科医生和瘤学家必须警系统性癌症治疗的眼部副作用.
- 早期识别和适当的治疗可以减轻视力丧失并改善患者的治疗结果.
- 需要进一步的研究来优化治疗方案,并尽量减少眼部发病率.
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