轨道前皮层刺激对精神分裂症EEG微态的直接和长期影响
Kexu Zhang1, Qiang Hu2, Yanli Zhang3
1Department of Physical Therapy, Shandong Daizhuang Hospital, Jining, China.
Translational psychiatry
|January 23, 2026
概括
轨道前皮层 (OFC) 的重复性横磁刺激 (rTMS) 改变了精神分裂症患者的大脑活动. 这种治疗显示出正常化EEG微态异常的潜力,这表明早期反应可以预测长期结果.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 电力生理学 电力生理学
背景情况:
- 针对轨道前皮层 (OFC) 的重复性横磁刺激 (rTMS) 显示出对精神分裂症治疗的前景.
- OFC-rTMS对精神分裂症患者大脑动态的直接和长期影响尚未完全理解.
研究的目的:
- 研究OFC-rTMS对精神分裂症患者和健康对照者的EEG微态的电生理学影响.
- 确定OFC-rTMS是否调节与精神分裂症相关的特定EEG微态特征.
- 探索早期EEG微态变化与长期临床反应之间的关系.
主要方法:
- 87名精神分裂症患者接受了20次1Hz的OFC-rTMS或假刺激.
- 51名健康对照组接受了一次活动性rTMS会话.
- 静止状态EEG数据在基线,第一次会议后和治疗后使用微态分析进行分析.
主要成果:
- 与对照人群相比,精神分裂症患者在微观状态C和D中表现出基线异常.
- 一次OFC-rTMS会话在患者和对照组中减少了微状态C的发生.
- 20次OFC-rTMS治疗导致患者微状态C持续下降,微状态D持续增加.
- 微观状态C的更大的立即减少与更好的临床反应相关.
结论:
- 在精神分裂症中,OFC-rTMS诱导了EEG微态的即时和长期调节.
- 这种治疗似乎能使异常微状态C模式正常化.
- 在OFC-rTMS之后的早期EEG微态变化可以预测治疗结果.
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