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Updated: Jan 25, 2026

Genome Engineering of Primary Human B Cells Using CRISPR/Cas9
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Published on: November 3, 2020

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克里斯普尔-卡斯9跨裂变受到侧面R循环,延长的间隔器和非活跃的HNH域的阻碍

Roser Montagud-Martínez1, Raúl Ruiz1, Sara Baldanta1

  • 1Institute for Integrative Systems Biology (I2SysBio), CSIC - University of Valencia, Paterna, Spain.

Nature communications
|January 23, 2026
PubMed
概括

CRISPR Cas9酶可以切割单链DNA. 它的RNA导向DNA处理受R环,导向RNA长度和特定的Cas9域的影响,允许其功能进行微调.

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