微生物群对神经发育的代际影响:机制和治疗观点
Ruo-Xi Wang1,2, Ali Afzal2,3, Xiao-Yuan Jing1,2
1Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Acta pharmacologica Sinica
|January 23, 2026
概括
肠道微生物群 (GM) 显著影响子孙的神经发育跨代,由母因子介导. 了解这些微生物群-肠-大脑轴机制,可以为神经发育障碍提供新的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发育生物学 发展生物学
背景情况:
- 神经发育是一个复杂的过程,受遗传学和环境的影响.
- 肠道微生物群 (GM) 在宿主生理学和神经发育中起着至关重要的作用.
- 人们越来越认识到转基因对后代大脑和行为的代际影响.
研究的目的:
- 审查转基因对神经发育的时间和代际影响.
- 探索微生物群-肠-大脑轴相互作用背后的机制.
- 通过转基因来突出母亲对后代神经发育的影响.
主要方法:
- 文献综述侧重于转基因的时间和代际影响.
- 机械路径的探索:表观遗传调节,神经递质调节,神经炎症和肠道屏障功能.
- 分析母亲的状态 (压力,饮食,炎症) 和它们对后代神经发育的影响.
主要成果:
- 基因转基因影响宿主生理和神经行为结果跨世代.
- 机制包括表观遗传变化,神经递质变化,神经炎症和肠道屏障完整性.
- 母亲的压力,饮食和炎症通过转基因介导途径影响后代的神经发育.
结论:
- 转基因是对母亲对后代神经发育的影响的关键调解者.
- 弥合从动物模型到人类的翻译差距至关重要.
- 整合多omics,计算建模和临床方法可以指导基于神经发育障碍的精确微生物群干预.
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