在慢性疼痛患者中,通过集群分析揭示了减少运动和轻度认知障碍之间的联系
Masamichi Moriya1,2,3, Masaki Kitahara2, Kenji Karako3
1Department of Physiology, Showa University School of Medicine, Shinagawa, Japan.
Advances in experimental medicine and biology
|January 23, 2026
概括
疼痛显著影响认知功能,增加轻度认知障碍 (MCI) 的风险. 对血液测试的深度学习分析揭示了疼痛患者的代谢变化和较低的微型精神状态检查 (MMSE) 估计得分,突出显示运动障碍是关键因素.
科学领域:
- 神经学 神经学
- 代谢障碍 代谢障碍 代谢障碍
- 人工智能在医学中的应用
背景情况:
- 认知障碍与全身代谢问题有关.
- 疼痛可能是影响整体健康和认知状态的重要因素.
研究的目的:
- 通过使用深度学习,估计外科医生有或没有疼痛的轻度认知障碍 (MCI) 的风险.
- 确定系统代谢障碍,疼痛和认知功能之间的相关性.
主要方法:
- 深度学习模型应用于一般血液检测数据.
- 单变量分析计算出估计的迷你心理状态考试 (MMSE) 成绩.
- 在评估电池数据上进行了主要组件和集群分析.
主要成果:
- 与对照组相比,疼痛患者的MMSE估计得分明显较低.
- 疼痛组显示出血液参数的改变:较高的白细胞,甘油三,葡萄糖,;较低的红细胞,血红蛋白,尿酸.
- 由第一个主要组成部分指出的流动性减少与显著较低的MMSE得分有关,这表明MCI风险增加.
结论:
- 系统代谢障碍,可能会因疼痛引起的不运动而加剧,增加轻度认知障碍的风险.
- 对血液检测的深度学习分析可以识别患MCI风险较高的个体.
- 疼痛管理和提高运动能力可能对预防认知能力下降至关重要.
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