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Updated: Jan 25, 2026

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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通过 thiophene S,S-二氧化物循环添加,对Strychnos 类化合物的集体不对称合成

Kun Ho 'Kenny' Park1, Jisook Park1, Nils Frank1

  • 1Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.

Nature chemistry
|January 23, 2026
PubMed
概括

提奥芬S,S-二氧化物能够快速,立体选择性合成斯特里克诺斯类化合物. 这种模块化方法为复杂的天然产品提供了简洁的路线,如,推进药物化学.

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