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大脑和高血压:从同情性外流到以大脑为中心的血压管理
Shota Ikeda1,2, Keisuke Shinohara3
1Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. ikedash@junnai.org.
高血压会损害大脑,而大脑调节血压 (BP). 了解这种联系是更好的预防和治疗的关键,强调中央途径作为治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 高血压是大脑功能障碍的主要原因和后果.
- 大脑控制自主神经系统的音调,影响血压.
- 与血压相关的伤害范围从中风到小血管疾病.
研究的目的:
- 审查同情感兴奋的中心机制最近的进展.
- 讨论关于高血压中脑血管结果的临床观点.
- 为了强调大脑健康和血压调节之间的不可分割关系.
主要方法:
- 审查最近关于中央通路的机理学研究.
- 对血压变化和脑血管结果的临床研究的分析.
- 对大脑氨酸 - 血管酶系统,黑色皮质素系统和肠-大脑轴的发现进行综合.
主要成果:
- 中央通路,包括大脑的氨酸-血管新生素系统和伊米达林受体agonists,调节同情活动.
- 脑血管结果取决于平均血压,血压变化和累积小血管疾病负担.
- 夜间血压激增,每次访问的变化和脉压是显著的风险因素.
结论:
- 中心途径为高血压管理提供了可行的治疗目标.
- 对BP模式和累积损伤的全面了解对于预测脑血管结果至关重要.
- 解决未经治疗的高血压,特别是年轻人,对于预防脑损伤至关重要.
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