自发与体外受精怀孕中的异质后代生长:一项回顾性队列研究
1Wuxi Maternity and Child Healthcare Hospital (Affiliated Women's Hospital of Jiangnan University), Wuxi, China.
Journal of assisted reproduction and genetics
|January 23, 2026
概括
与自发受孕相比,通过冷胚胎移植 (FET) 怀孕的儿童体重增加和BMI更高. 监测辅助生殖技术 (ART) 怀孕儿童的生长是非常重要的.
科学领域:
- 儿科 儿科 儿科
- 生殖医学 生殖医学
- 儿童发展 儿童发展
背景情况:
- 观察性研究表明,通过体外受精和胚胎移植 (IVF-ET) 怀孕的儿童的潜在生长差异.
- 冷与新鲜胚胎移植对早期儿童发育的具体影响需要进一步研究.
研究的目的:
- 根据受孕方式来比较儿童的早期身体发育:自发受孕 (SC),冷胚胎移植 (FET) 和新鲜胚胎移植 (新鲜ET).
- 评估FET和新鲜ET对从出生到五岁的生长模式的不同影响.
主要方法:
- 对5,821名儿童 (2010-2021) 的人体测量数据进行了纵向分析.
- 包括2,958个SC,2,148个FET和715个新的ET病例.
- 使用线性混合效应模型,分层分为单胎和双胎怀孕.
主要成果:
- 对于单身,FET与SC相比,与更高的体重,体重增加速度,BMIz-score和体重对身高z-score (WHZ) 有关.
- 新鲜ET在单人中增加了体重和身高增长速度,但不是最终体重或BMI/WHZ.
- 在双胞胎中,FET显著增加了体重,体重增加速度,BMI z-score和WHZ;新鲜的ET只增加了体重增加速度和BMI z-score.
结论:
- 对于通过不同的辅助生殖技术 (ART) 方法怀孕的儿童,存在不同的早期儿童生长轨迹.
- 与SC相比,FET与加速体重增加和更高的BMI/WHZ得分有关.
- 对于通过ART怀孕的孩子来说,生长监测至关重要.
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