白质发育的两个轴.
Audrey C Luo1,2,3, Steven L Meisler1,2,3, Valerie J Sydnor4
1Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nature communications
|January 23, 2026
概括
人类白质的发育在主要路径上呈现出明显的模式. 表面区域的成熟时间较晚,遵循传感运动到关联等级,挑战统一的成熟假设.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 神经成像是一种神经成像.
背景情况:
- 了解白质成熟对于认知发育至关重要.
- 以前的研究通常假定沿着白质片段的均发展.
- 沿着主要区域的人类白质的发育仍然在很大程度上没有特征.
研究的目的:
- 为了确定白质成熟的基本模式沿着人类主要的路径.
- 为了研究在皮层-皮层通道的长度上的发育变异.
- 挑战统一白质管道发育的假设.
主要方法:
- 利用来自三个大规模的横截面数据集 (N=2716) 的扩散MRI数据.
- 检查了5-23岁年轻人的发育变异.
- 分析了主要的,远程的皮层-皮层区域.
主要成果:
- 确定了白质发育的两个可复制的轴:深层到表面轴和感觉运动到关联等级轴.
- 皮层附近的表面通道区域显示出与年龄相关的变化比深层区域更大.
- 表面通道的发育与皮层层次一致,感觉运动相邻区域比协会相邻区域更早成熟.
结论:
- 白质区域在其长度上不均成熟.
- 沿途的发育变异具有潜在的功能影响,例如减轻触觉合和调整神经同步.
- 这些发现提升了我们对青春期神经传输细化过程的理解.
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