癌症患者肠道乙酸环酶编码细菌的丰度发生变化
Francesco Candeliere1, Laura Sola1, Enrico Busi1
1Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
Scientific reports
|January 23, 2026
概括
循环二-AMP (c-di-AMP),一种细菌分子,影响瘤免疫力. 产生C-di-AMP的细菌在癌症患者中较少,这表明它们在抗瘤反应中的作用.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 循环二-AMP (c-di-AMP) 是一种细菌的第二信使,它可以激活宿主免疫传感器,特别是STING通路.
- 这种相互作用将肠道微生物群活动与瘤免疫联系起来,为癌症患者提供治疗潜力.
- 新出现的证据表明,微生物c-di-AMP可以增强抗瘤反应,并增强PD-1/PD-L1阻断和放射治疗等治疗方法.
研究的目的:
- 为了确定能够合成c-di-AMP的肠道微生物物种.
- 为了分析健康个体与癌症患者中的c-di-AMP产生细菌的丰富程度.
- 探索c-di-AMP产生细菌与对癌症免疫疗法的反应之间的关系.
主要方法:
- 挖掘人类胃肠道蛋白质统一目录中的二甲基酸环酸酶 (DACs).
- 在众多微生物物种中建立一个全面的DAC数据库.
- 分析健康受试者和癌症患者 (黑色素瘤,NSCLC,癌) 的元基因组数据.
主要成果:
- 从3,901个物种中生成了一个包含4,228个DAC的数据库.
- 与癌症相关的微生物群相比,编码DAC的物种在健康的微生物群中显著更多.
- 在免疫疗法响应者和不响应者之间,没有观察到DAC编码物种丰度的显著差异.
结论:
- 在癌症患者的微生物群中,产生C-di-AMP的细菌被耗尽.
- 这些发现凸显了c-di-AMP产生细菌在调节抗瘤免疫力方面的潜在作用.
- 需要进一步的研究来研究这些细菌在瘤学中的治疗含义.
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