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zDUR:具有高压缩比和速度的无参考FASTQ压缩机
Artem Ershov1, Renpeng Ding1, Qian Fu1
1MGI Tech, BGI, Shenzhen, 518083, China.
BMC bioinformatics
|January 23, 2026
概括
zDUR是一个新的无引用FASTQ压缩机,可以高效地处理下一代测序数据. 它提供了平衡的压缩比率和速度方法,在各种数据类型上优于现有的方法.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 高通量序列生成大型FASTQ文件,需要高效的压缩来存储和传输.
- 专用FASTQ压缩机通过利用数据冗余性提供了比通用压缩机更好的性能.
- 现有的FASTQ压缩机通常具有有限的数据适用性或压缩比和速度之间的妥协.
研究的目的:
- 开发一个无参考的FASTQ压缩机,具有广泛的数据适用性和压缩比与速度之间的平衡.
- 解决现有的专用FASTQ压缩机在数据兼容性和性能权衡方面的局限性.
主要方法:
- 开发zDUR,一个新的无参考FASTQ压缩算法.
- 使用15个不同的数据集,对zDUR与其他六个无参考压缩机进行了比较.
- 在单细胞RNA-seq,空间转录组学和其他测序数据类型中评估压缩比,速度和适用性.
主要成果:
- 在各种测序数据类型中,zdur显示了压缩比和速度之间的良好平衡.
- 15个数据集的基准测试表明zDUR的广泛适用性.
- 与SPRING相比,zdur在单细胞RNA-seq和空间转录组学数据上的运行时间性能提高了十倍以上,同时保持了优越的压缩比率.
结论:
- zDUR提供了一个可扩展和高效的解决方案,用于无引用的FASTQ数据压缩.
- 压缩机平衡了性能,速度和可用性,用于各种下一代测序数据集.
- zDUR代表了处理大量测序数据的存储和传输挑战的进步.
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