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在中国的儿科血造干细胞移植中使用抗菌剂:一项回顾性多中心队列研究
Ying Cui1, Haixin Cheng2, Biqing Liu2
1Department of Pharmacy, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Beijing, China. cuiyingcpuyaoli@163.com.
BMC pediatrics
|January 23, 2026
概括
儿科造血干细胞移植 (HSCT) 患者通常会接受宽谱抗微生物和抗真菌药物适度持续时间. 治疗长度没有显示出基于年龄的显著差异.
科学领域:
- 儿科血液学 儿科血液学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 造血干细胞移植 (HSCT) 对于治疗儿科血液性恶性瘤和非恶性疾病至关重要.
- 感染构成重大威胁,导致儿科HSCT接受者的发病率和死亡率.
- 在这种脆弱人群中,抗菌剂的应用需要仔细评估.
研究的目的:
- 评估抗微生物和抗真菌剂在儿科HSCT中的利用模式.
- 分析使用的药物类型及其治疗持续时间.
- 为了确定抗微生物治疗中的任何与年龄相关的差异.
主要方法:
- 一项多中心的回顾性观察队列研究,涉及中国21家医院.
- 包括从2023年1月到2024年4月接受HSCT并接受抗菌治疗的儿科患者.
- 收集关于疾病类型,抗菌素使用 (抗生素,抗真菌药物) 和治疗持续时间的数据,并根据年龄分别对子组进行分析.
主要成果:
- 分析了186名儿科患者 (73名瘤组,113名非瘤组).
- 最常见的疾病:急性淋巴细胞白血病 (瘤组) 和粘多糖 (非瘤组).
- 经常使用:皮佩拉西林-塔扎巴克坦 (抗生素),可纳和沃里可纳 (抗真菌药). 抗菌治疗的中位数为10天 (7-14天范围).
结论:
- 儿科HSCT患者主要接受广泛的抗菌和抗真菌疗法.
- 治疗持续时间一般是中等的.
- 学龄儿童的治疗周期略长,但没有统计学意义.
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