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内法利西马布注射后眼内炎症:一个病例系列
Yunhua Loo1, Joshua Lim1, Milton Cher Yong Chew1
1Singapore National Eye Centre, Singapore.
Clinical & experimental ophthalmology
|January 24, 2026
概括
在faricimab注射后,眼内炎症 (IOI) 可能发生,呈高血压性脑膜炎. 迅速管理眼内压力对于预防视力丧失至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 眼内炎症 (IOI) 是一种罕见但严重的并发症,发生在内抗血管内皮生长因子 (anti-VEGF) 注射后.
- IOI的发病率有所增加,特别是在较新的抗VEGF药物中.
- 法里西马布是最近批准的抗VEGF药物,目前正在收集安全数据.
研究的目的:
- 报告眼内炎症 (IOI) 病例后,内法利西马布注射.
- 描述法里西马布使用后IOI的临床表现和结果.
主要方法:
- 追溯的案例系列.
- 涉及5名患者的8只眼睛,这些患者在法里西马布静脉内注射后发展了IOI.
主要成果:
- 所有患者都呈现出显著的膜炎和前玻璃体参与.
- 四名患者出现了亚急性高血压性眼膜炎;一名患者出现了急性呈现,眼内压力正常.
- 在停止法里西马布治疗并开始抗炎治疗后,所有患者的炎症都消失了.
结论:
- 非传染性高血压性脑膜炎可能发生在内法利西马布注射后.
- 及时管理眼内压力是防止青光眼损伤的必要条件.
- 区分IOI和传染性内炎至关重要,以避免不适当的抗生素和手术干预.
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