抗抑郁药使用对关节骨折后并发症的影响管理:多机构倾向匹配的队列分析
Amir Alsaidi1, Abdullah Ghali2, Katie McBee2
1Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, Department of Orthopaedic Surgery and Rehabilitation, El Paso, TX, USA.
Foot & ankle international
|January 24, 2026
概括
在关节手术前使用抗抑郁药与更多的并发症有关. 服用抗抑郁药物的患者经历了更高的短期问题比如感染和长期问题比如硬件故障后脚开放减少内部固定 (ORIF).
科学领域:
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
- 患者安全 患者安全
背景情况:
- 评估抗抑郁药物处方 (ADP) 对骨科手术后患者结果的影响.
- 专注于关节开放缩减内部固定 (ORIF) 作为一个特定的外科背景.
- 调查心理健康药物和手术并发症率之间的潜在联系.
研究的目的:
- 为了确定抗抑郁药使用与手术后并发症之间的关联,在接受脚ORIF的患者中.
- 在这个患者群体中量化短期和长期并发症的风险.
- 为服用抗抑郁药物的患者提供术后护理策略的信息.
主要方法:
- 使用多机构Trinetx数据进行的回顾性队列研究.
- 纳入标准:脚ORIF,至少2次ADP剂量,2年的随访.
- 分析使用了CPT和ICD-10代码,控制了Benjamin-Hochberg的错误发现率.
主要成果:
- 在70,813名患者中,有19.2%使用抗抑郁药.
- 服用抗抑郁药的患者出现较高的短期并发症 (感染,伤口破坏,再入院).
- 观察到两年后机械并发症 (硬件故障,关节炎,非工会,截肢) 的显著增加.
结论:
- 手术前的抗抑郁药处方与关节ORIF后的术后和长期并发症的增加有关.
- 这些发现凸显了需要量身定制的经营期间管理的需要.
- 对于手术前处方抗抑郁药的患者,建议加强监测.
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