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冠状病毒后疾病 (COVID-19) 刺激性肠综合征:我们到目前为止所学到的知识
Uday C Ghoshal1, Rajan Singh2, Mahesh K Goenka1
1Institute of Gastrosciences & Liver Transplantation, Apollo Multispeciality Hospitals, Kolkata, West Bengal, India.
COVID-19 感染导致刺激性肠综合征 (IBS) 诊断增加了 7.2%,突出显示了肠-大脑轴连接. 了解这些感染后肠-大脑相互作用对于开发向疗法至关重要.
科学领域:
- 胃肠病学和神经病学
- 肠-大脑轴研究研究
- 传染病流行病学 传染病流行病学
背景情况:
- 随着COVID-19大流行,肠-大脑相互作用障碍 (DGBIs) 的增加,特别是感染后IBS (PI-IBS).
- SARS-CoV-2的胃肠道热带和与大流行有关的压力因素有助于这种增加.
研究的目的:
- 审查和分析有关后COVID-19IBS的流行率,临床特征和预测因素的当前证据.
- 将机械学的见解纳入COVID-19后IBS的病理生理学.
- 确定治疗点,并为COVID-19后IBS提供个性化管理策略.
主要方法:
- 对现有文献进行了叙事审查.
- 分析包括基于人口的调查和新兴研究数据.
主要成果:
- 大约7.2%的人患上SARS-CoV-2后IBS感染,与未感染的人相比增加了2.6倍.
- 美国的一项调查显示,在疫情期间IBS患病率急剧上升,其他DGBIs保持稳定.
- 机制包括ACE2相互作用,炎症,微生物群变化,血清素信号传递,肠道屏障功能障碍和心理社会压力.
结论:
- DGBIs,特别是IBS,影响7.2%的SARS-CoV-2感染后患者.
- 建议针对表型量身定制的多学科护理用于诊断和管理.
- 未来的研究应该使用罗马五号标准,控制混因素,并为精密疗法定义机械内型.
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