维生素D缺乏和发生性心房动/动的风险:一个多中心纵向队列研究
Ching-Chung Ko1,2,3, Ting-Sian Yu4, Kuo-Chuan Hung5
1Department of Medical Imaging, Chi Mei Medical Center, Tainan City, Taiwan.
Medicine
|January 24, 2026
概括
维生素D缺乏 (VDD) 显著增加患心房 (AF) 的风险,这种风险取决于剂量. 这项大型研究证实VDD是AF和相关心血管事件的可修改风险因素.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 关于维生素D缺乏症 (VDD) 与发生的心房/ (AF) 之间的关联,存在相互矛盾的证据.
- 以前的研究主要是横截面的,限制了因果推断.
- 需要一个强大的纵向评估来澄清这种关系.
研究的目的:
- 用一个大规模的,多机构的队列来调查VDD和事件AF之间的关联.
- 评估维生素D水平和AF风险之间的剂量反应关系.
- 探索潜在的改变因素和其他相关风险.
主要方法:
- 使用TriNetX平台 (2010-2023) 的纵向队列研究.
- 包括40岁以上的个体,两次血清25-氧维生素D测量.
- 1:1倾向性得分匹配与持续VDD (<20 ng/mL) 与对照组 (≥30 ng/mL) 相比;主要结局:发生AF在3年内.
主要成果:
- 在对每组137,407名患者进行匹配后,VDD与较高的AF风险显著相关 (HR:1.83).
- 观察到一种剂量反应关系:严重缺乏 (<10 ng/mL) HR 1.90,中度 (10-20 ng/mL) HR 1.94,不足 (20-30 ng/mL) HR 1.60.
- VDD还与缺血性中风和肺炎风险增加相关;失脂症改变了VDD-AF关联.
结论:
- VDD与剂量依赖的方式增加事件AF风险显著相关.
- 这些发现支持VDD作为一种潜在的可修改的心血管风险因素.
- 需要进一步的研究来验证这些发现并阐明机制.
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