结性脊柱炎的生物疗法现状和新兴趋势:一个文献计量分析 (2004-2024)
Rong Deng1, Xuan Jiang1, Xin-Xin Zhong2
1Department of Orthopedics and Traumatology, Yongzhou Hospital of Traditional Chinese Medicine, Yongzhou, China.
Medicine
|January 24, 2026
概括
对结性脊柱炎 (AS) 生物疗法的研究急剧增加,其中关键领域包括疗效和个性化治疗. 未来的研究将集中在针对肠道微生物群的新生物和疗法上.
科学领域:
- 风湿病学和免疫学
- 药理学和治疗学 药理学和治疗学
背景情况:
- 脊髓缩性脊柱炎 (AS) 是一种慢性炎症性疾病,影响脊柱和生活质量.
- 生物疗法,包括TNF-α,IL-17和JAK抑制剂,为AS提供了新的治疗途径.
- 了解研究趋势对于推进AS管理至关重要.
研究的目的:
- 进行对结性脊柱炎 (AS) 生物疗法研究的文献分析.
- 确定关键的研究趋势,有影响力的出版物和AS生物治疗研究的未来方向.
主要方法:
- 用Web of Science和PubMed. 的方法对2004-2024年的研究进行了图书统计分析.
- 使用CiteSpace和VOSviewer分析出版趋势,引用模式和研究热点.
- 确定领先的国家,关键研究领域,以及大量引用的出版物.
主要成果:
- 20多年来,AS生物治疗研究的显著增长,由美国,中国和德国领导.
- 关键的研究领域包括治疗疗效,个性化策略和组合疗法.
- 高度引用的研究重点是TNF-α抑制剂,IL-17抑制剂和新兴的JAK抑制剂.
结论:
- 图书统计分析揭示了对AS的日益兴趣,并确定了AS生物疗法的研究缺口.
- 需要对AS的长期疗效,安全性和个性化/组合治疗进行进一步的研究.
- 未来的方向包括双重目标生物药物,新型细胞因子通路,基因疗法和微生物群影响.
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