血清mir-181a作为代谢功能障碍相关的脂肪肝疾病的潜在血清生物标志物:一个横截面研究
Ke-Gong Xiong1, Jin-Feng Kong, Tai-Shun Lin
1Department of Hepatology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China.
在代谢功能障碍相关的脂肪肝病 (MAFLD) 患者中,血清微RNA-181a (miR-181a) 水平升高. 这项研究表明miR-181a是MAFLD诊断和进展的潜在生物标志物.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的全球健康问题.
- 早期诊断和对MAFLD病原体的理解对于有效的管理至关重要.
- 微RNAs (miRNAs) 在肝脏疾病的发展中起着重要作用.
研究的目的:
- 在患有MAFLD的患者中研究血清microRNA-181a (miR-181a) 的表达水平.
- 评估血清miR-181a在MAFLD中的临床意义和诊断潜力.
- 探索miR-181a与代谢参数,肝损伤和MAFLD中的纤维化之间的关联.
主要方法:
- 采用了横截面研究设计,招募了MAFLD患者和非MAFLD对照.
- 血清样本从2023年1月到2024年12月收集.
- 使用实时定量聚合酶链反应 (RT-qPCR) 来量化血清miR-181a水平.
主要成果:
- 与对照组相比,MAFLD患者的血清miR-181a水平显著更高 (1.15±0.50对比0.79±0.39,P<.001).
- 升高的miR-181a表达与MAFLD独立相关 (OR = 2.295,P = .011) 并与不良代谢参数,肝损伤和纤维化有关.
- 在诊断MAFLD时血清miR-181a的最佳切线值为0.90,AUC为0.80,灵敏度为77.50%,特异性为76.67%.
结论:
- 在MAFLD患者中,血清miR-181a显著上调.
- miR-181a与MAFLD的发病和进展有关.
- 血清miR-181a显示为MAFLD诊断的非侵入性血清生物标志物具有前途.
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