肝瘤免疫疗法研究的过去,现在和未来:一个图库计量和可视化分析
Wenxia Ma1, Ling Wang2, Yan Niu2
1Nursing Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Medicine
|January 24, 2026
概括
对肝脏新生瘤的免疫疗法研究正在迅速扩大,在2021年之后出版物的数量显著增加. 关键领域包括瘤微环境和T细胞,突出显示全球对这种治疗越来越感兴趣.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 图书统计学 图书统计学
背景情况:
- 肝脏瘤是一个重大的全球健康威胁.
- 近年来,免疫疗法已经取得了相当大的治疗成功.
- 图书统计分析为研究趋势和发现提供了洞察力.
研究的目的:
- 要总结目前肝脏瘤免疫治疗的研究格局.
- 确定该领域的关键发现和新兴方向.
- 分析出版趋势和有影响力的贡献者.
主要方法:
- 从Web of Science核心集合 (2014-2024) 中对1663篇英语文章进行了图书统计分析.
- 使用Microsoft Excel和CiteSpace进行数据可视化和计算.
- 识别领先的国家,机构,作者和高度引用的参考文献.
主要成果:
- 2021年以后,有关肝瘤免疫治疗的出版物迅速增加.
- 中国,中国科学院和Tim F. Greten是最多产的贡献者.
- 索拉芬尼,瘤微环境,T细胞和树突细胞是关键的研究领域.
结论:
- 对肝脏瘤免疫治疗的研究兴趣正在加速.
- 全球研究成果与疾病发病率相关,但显示出发达国家与发展中国家之间的差异.
- 未来的研究应该专注于确定的密集研究领域,如瘤微环境和细胞免疫疗法.
相关概念视频
Tumor Immunotherapy
1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Liver Histology
4.2K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
4.2K
Liver Physiology
3.6K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.6K
Liver Regeneration
4.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
Gross Anatomy of the Liver
2.0K
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.0K
Diseases of the Liver and Gallbladder
1.9K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.9K


