作为基本生物标记物的维特洛根因:二对斑马鱼 (Danio Rerio) 的内分泌干扰作用
Rabia Şemsi1, Aysel Çağlan Günal2, Rabia Tural1
1Department of Medical Biochemistry, Institute of Health Sciences, Gazi University, Ankara, Türkiye.
Journal of applied toxicology : JAT
|January 24, 2026
概括
在雄性斑马鱼中,甲 (NaPT) 暴露显著增加了维特洛金 (Vtg) 水平,表明潜在的内分泌干扰. 这凸显了生物制剂在海洋污染中的生态系统和人类健康风险.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 海洋生物学 海洋生物学
背景情况:
- 由于人口过剩和消费,环境污染物正在增加.
- 甲 (NaPT) 是一种广泛使用的抗微生物和抗真菌剂.
- 维特洛根因 (Vtg) 是一种对雌激素有反应的生物标志物,对于检测内分泌干扰至关重要.
研究的目的:
- 研究NaPT暴露对成年雄性斑马鱼全身Vtg水平的影响.
- 评估NaPT作为内分泌干扰化学物质 (EDC) 的潜力,使用Vtg诱导作为关键终点.
主要方法:
- 成年雄性斑马鱼被暴露在1和5μg/L的NaPT中24小时,72小时,96小时和7天.
- 通过使用商业ELISA套件量化全身Vtg水平.
- 进行了统计分析,以比较暴露组和对照组之间的Vtg水平.
主要成果:
- 与对照组相比,NaPT暴露在所有测试时间点上显著增加了斑马鱼的Vtg水平 (p < 0.05).
- 在24小时内,在低剂量和高剂量NaPT之间观察到Vtg水平的显著差异 (p = 0.009).
- 结果表明,NaPT对Vtg表达的作用取决于剂量和时间.
结论:
- 暴露NaPT诱导斑马鱼Vtg表达的显著变化,表明内分泌干扰的潜力.
- 像NaPT这样的杀生物产品对非目标生物和生态系统健康构成风险.
- 这些发现强调了包括EDC在内的海洋污染对生态系统和人类福祉的潜在风险.
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